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Cover: Sunflower hybrid Sanbro_MR growing at the experimental fields of Mediterranean Agronomic Institute of Bari, Valenzano, Italy, and irrigated via drip system. Photo credit: Ljubomir Zivotic. Can simulation models simulate various agronomic practices well enough to evaluate crop water use efficiency? The nine papers in this special section (423–521) of Agronomy Journal explore how four simulation models and different management strategies were used to simulate yield, water use, and water use efficiency of four crops grown in North and South America, Europe, and the Middle East. The AquaCrop logo is an FAO (Rome) design.